I’ve been heating the injection site for the past couple of injections and it has worked out OK. The warmth seems to be a bit of a tradeoff – you can feel the needle go in a little more but then the medication going in doesn’t hurt nearly as much. It almost seems, with the ice pack, that the area gets tense and there isn’t enough space to cram the injection into where the warmth seems to make the tissue more pliable. The needle doesn’t really hurt anymore going in but it has been more noticeable. I will keep doing the warm towel because it beats the heck out of putting something freezing cold on your body! I have been using a dish towel that I warm in the microwave but will probably get a Sodium Acetate heating pack (these are the ones with the metal disc) since that will be much easier to use and are reusable plus I don’t have to worry about it getting too hot – they peak around 130 degrees.